On chloroform and other anæsthetics: their action and administrationSnow, John
History
On chloroform and other anæsthetics: their action and administration
Snow, John
Anesthetics; Chloroform; Snow, John, 1813-1858
A consideration of the symptoms in this case confirms the view that the
death was not caused by chloroform. In six of the fatal cases related
above, death took place instantaneously, without insensibility or any of
the usual effects of chloroform having been produced; but the mode of
dying was not the same as in Mr. Robinson’s patient. In Case 4, that of
Madlle. Stock, the patient said “I choke”, and tried to push away the
handkerchief; then there was embarrassed breathing and foaming at the
mouth. In Case 11, that of Madame Labrune, the fatal attack followed
immediately on a full inspiration of chloroform, and there was an
immediate alteration of the features, and a convulsive rolling of the
eyes, amongst other symptoms. In Case 14, the young lady stretched
herself out, and frothed at the mouth, at the moment of the fatal
attack, and the face became livid. In Case 26, that of Madame W., who
died at Ulm, the voice, when answering the question about singing in her
ears, was trembling and thick; she stretched out her limbs, and the face
became bluish. In Case 45, that of the wife of a medical man, and in 46,
that of Dr. Roberts’s patient in Edinburgh, there was a convulsive start
at the moment of the sudden death. It thus appears that when the heart
is suddenly paralysed by an overdose of chloroform, before the patient
is rendered insensible, there are usually some symptoms as if of a
violent shock or injury. After complete insensibility is induced, the
heart may be suddenly paralysed by chloroform, as is shown by numerous
cases, without this spasmodic action; and it would perhaps be premature
to deny that a patient might die thus quietly without being first made
insensible; and the nature of the death in this particular case must be
chiefly decided by the physical fact that the patient could not have
inhaled enough chloroform to produce an appreciable effect of any kind,
much less to cause sudden death.
At the inspection of the body, the liver was found so much enlarged that
it weighed eight pounds, and it encroached very much on the chest. The
walls of the left ventricle of the heart were found thinner than
natural, and the muscular tissue was interspersed with fatty
degeneration. There was blood in the right auricle and in both
ventricles. In the ventricles it was partly coagulated. The brain
presented nothing abnormal.[127]
It is probable that the immediate cause of death in this instance was
fear. The patient had been told in the country that it would be unsafe
for him to take chloroform, and yet he could not summon resolution to
undergo the operation without it. Mr. Robinson unfortunately allowed his
patient to remain seated in the operating chair; and it was only when
Dr. Waters had been sent for and arrived from a neighbouring street that
he was laid on the floor.
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