On September 15th, 1852, a patient died to whom I was administering chloroform whilst Mr. Cæsar Hawkins was performing lithotrity. He was a gentleman from the country, aged seventy-three; he was tall and stout, he had a weak intermitting pulse, and a well marked arcus senilis in each cornea. He had inhaled chloroform five or six times, between May 1850 and May 1851, for the same operation, when under the treatment of another surgeon, and it always acted favourably. In the first week of December 1851, Mr. Hawkins performed the operation of lithotrity twice, when the chloroform was administered by Mr. Geo. D. Pollock. On the second of these occasions he became faint during the operation whilst under the influence of the chloroform, but recovered from the faintness before its conclusion. He again fell into a very alarming state of syncope a few minutes after the conclusion of the operation, but rallied, and vomited the breakfast which he had taken a little time before. I first administered the chloroform to this patient on December 15th, 1851, eleven days after the above occurrence. Mr. Hawkins and I were inclined to think that the alarming syncope on the previous occasion might have been connected with the sickness which occurred. It was my firm belief that the patient had fatty disease of the heart; but I did not see any great objection to the chloroform on that account, as I had frequently given it in similar cases, and always with a favourable result. On this occasion (December 15th) he inhaled the chloroform before breakfast. Its effects were quite satisfactory, and it was not accompanied or followed by any unpleasant symptoms whatever. The operation was repeated four days afterwards, when I again exhibited the chloroform with like favourable results. After this the patient went back to the country relieved from his stone. He came back, however, in the autumn of 1852, with a return of his complaint, and I was again requested by Mr. Hawkins to assist him by giving the chloroform on September 15th.