The quantity of chloroform administered during any one pain, never exceeds a very few minims; but the quantity used in the course of a protracted labour is often considerable. I have several times used from four to six ounces; and in one case, at which I was present the greater part of the time, seventeen fluid ounces of chloroform were used with the inhaler, which would produce as much effect as three or four pounds used on a handkerchief. The inhalation was continued with intermissions over a period of thirty-one hours. The patient was unconscious during the greater part of the last five or six hours, but previously to this, her constant complaint was that she had not enough chloroform. She was the wife of a physician, was thirty-seven years of age, and in her first confinement. The membranes ruptured early. The labour was natural, but there was excessive sensibility. The first twenty-six hours of intermitted inhalation were during the first stage of labour. Chloroform can be best applied when there is an additional medical man, who has not to attend to the ordinary duties of the accoucheur; but it can be given very well by the accoucheur himself, so as to save the greater part of the suffering of labour; although he perhaps cannot always administer it in the perfect way in which he could, if he had no other duties to divide his attention. It is probable that the use of chloroform has no particular influence over the duration of labour, in the whole number of cases in which it is employed; but individual labours are occasionally either retarded or quickened by it, according to circumstances. In some cases, the chloroform, even when very moderately employed, diminishes both the strength and the duration of the uterine contractions, and prolongs the interval between them, thereby making the labour somewhat longer—a matter of no consequence, however, as the patient is not suffering in any way. In other cases, the inhalation causes the uterine action to become stronger and more regular, by removing the excess of sensibility by which it has been interfered with. This occurs more particularly in the first stage of labour. In some cases, also, the chloroform seems to act as a direct stimulant to the uterine contractions, increasing their force and frequency—a circumstance at which we need not be surprised, when we remember that both opium and brandy, in moderate quantity, often act in the same manner. Chloroform has also the effect of promoting the dilatation of the os uteri in many cases, even when no rigidity exists; and when there is rigidity of the os uteri, the inhalation is of the utmost service, and shortens labour very much. This is the case, also, when there is rigidity of the perineum.