In using the inhaler described above, the patient should commence to inhale with the expiratory valve of the face-piece turned on one side, and it should be gradually advanced to the required extent, over the opening it is intended to cover, as the sensibility of the lungs becomes diminished. Not only patients with phthisis or bronchitis, but many sensitive and irritable persons with sound lungs, have a great intolerance of the vapour of chloroform at first, on account of its pungency; and it is necessary to occupy two or three minutes in gradually commencing the inhalation, before the patient makes any appreciable progress towards insensibility. In administering chloroform to children also, it is desirable to begin very gently; by this means, and with a little persuasion, one generally succeeds in getting them to inhale voluntarily; although, occasionally, it is necessary to use a little force to accomplish one’s purpose. In certain cases of the medicinal application of chloroform, and also in obstetric cases, where the pains are not severe, it is unnecessary to render the patient unconscious, but for surgical operations this is nearly always requisite. No force should ever be employed so long as the patient is conscious, unless it be to children or lunatics; but some patients become excited as soon as they are unconscious, and attempt to leave the couch, or push away the chloroform; under such circumstances, if they cannot be calmed by what is said to them, they should be held, and the vapour should be steadily and gently continued, for a minute or two, till a state of quietude is produced. By far the greater number of patients remain quiet as they become unconscious, but there is no difficulty in ascertaining whether a patient is unconscious or not. If the eyelids remain open, the countenance shows whether the patient is conscious or not; and, if they are closed, it is only necessary to touch them gently, to ascertain this circumstance. If he is still conscious, he will look at his medical man, and probably speak, or, at all events, show intelligence in his countenance.