On Digestive Proteolysis: Being the Cartwright Lectures for 1894Chittenden, R. H. (Russell Henry)
Science
On Digestive Proteolysis: Being the Cartwright Lectures for 1894
Chittenden, R. H. (Russell Henry)
Digestion; Digestive enzymes; Enzymes
With reference to the action of the stomach-mucosa on proteoses, it
has been shown[219] that when relatively large amounts (5 grammes)
are introduced into the stomach of a rabbit, the pylorus being
ligatured, both proteoses and peptones may appear in the urine, thus
indicating that while they may be absorbed to some extent under the
above conditions, the proteoses are not readily transformed into
native proteids without exposure to the intestine. Smaller amounts
(2 grammes), however, may, under the above conditions, be completely
transformed; at least Hildebrandt claims this to be the case, mainly on
the ground that after the introduction of albumoses into the stomach,
the pylorus being ligatured, no trace of them can be found in the
urine. The same observer also claims that blood-serum, in the case of
dogs, is able to transform albumoses into ordinary serum-globulin.
Certainly, after intra-venous injection, proteoses disappear from the
blood, but, as we shall see later on, a certain amount, at least, may
be transferred to the lymph. It is also claimed that when albumoses
are injected subcutaneously, neither albumoses nor peptones are to be
detected in the urine. This, however, seems hardly probable in the
light of what has been said, and especially in view of the fact that
Neumeister’s experiments tend to show that even 0.1 gramme of albumoses
introduced subcutaneously may give rise to temporary albuminuria.
[219] Hildebrandt: Zur Frage nach dem Nährwerth der Albumosen,
Zeitschr. f. physiol. Chem., Band 18, p. 180.
Public-domain text, read in full here on John Shaqi.
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