On Digestive Proteolysis: Being the Cartwright Lectures for 1894Chittenden, R. H. (Russell Henry)
Science
On Digestive Proteolysis: Being the Cartwright Lectures for 1894
Chittenden, R. H. (Russell Henry)
Digestion; Digestive enzymes; Enzymes
Thus, my interpretation of these results would lead me simply to the
admission that, possibly, a portion of the products of proteolysis
might pass from the intestine into the blood-current indirectly,
through the bodies of the leucocytes formed in the adenoid tissue
of the intestine. But even admitting this, we lack positive proof
of any direct transformation of proteoses and peptones into the
organized material of the white blood-corpuscles, for it may be that
the above products are first transformed through other agencies into
serum-albumin, or other like proteids. There are, indeed, many facts
which are plainly opposed to any marked absorption and transformation
of peptones by the leucocytes of the intestinal mucous membrane. Thus,
Heidenhain[227] has severely criticised the theory on the ground that
there is very little increase in the flow of lymph from the thoracic
duct during absorption, and further that the small percentage of
proteid matter in the chyle (about 2.0 per cent.) cannot account for
the large amount of proteid absorbed. Further, the objection is made
that the leucocytes present in the intestinal mucosa, though numerous,
are wholly inadequate to assimilate any large proportion of the
ingested proteid food.
[227] Beiträge zur Histologie und Physiologie des Dünndarms, Pflüger’s
Archiv f. Physiol, Band 43, Supplement Heft.
Still greater stress, however, may be laid upon the fact that
experimental evidence points to the conclusion that lymph-cells
cannot assimilate either peptones or proteoses. Thus, quite recently,
Shore[228] has studied the results following the introduction of a
mixture of such products into the lymphatic system by secretion,
by absorption, and by direct injection into a lymphatic vessel.
Preliminary experiments on dogs showed that when peptone is introduced
into the bile-duct it gradually appears in the lymph of the thoracic
duct, consequently this method can be made use of as a means of
ascertaining the fate of peptone so absorbed into the lymphatic system.
The results obtained, using the ammonium sulphate method for the
isolation of the peptone, showed that when peptone is injected into
the bile-duct with sufficient force to overcome the low pressure under
which bile is secreted, there is an increase in the rate of flow of
lymph from the thoracic duct. Further, while peptone is somewhat slow
in appearing in the lymph it eventually makes its appearance there, in
from sixty to one hundred and forty minutes after its injection into
the bile-duct. A certain amount of peptone naturally passes into the
blood, but is then rapidly excreted through the urine. When, however,
the renal vessels are ligatured, peptone still rapidly disappears from
the blood, but then passes into the lymph, and under such circumstances
can be detected in the lymph as early as thirty-eight minutes after its
injection into the bile-duct. These results, therefore, do not accord
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