On Digestive Proteolysis: Being the Cartwright Lectures for 1894Chittenden, R. H. (Russell Henry)
Science
On Digestive Proteolysis: Being the Cartwright Lectures for 1894
Chittenden, R. H. (Russell Henry)
Digestion; Digestive enzymes; Enzymes
We may well attribute to the epithelial cells of the intestine the
power, under normal circumstances, of regulating and controlling, even
though indirectly, the order of events in the intestine. Just as the
so-called secreting cells of the _tubuli uriniferi_ may lose for a time
their power to pick out from the blood material destined for the urine,
being clogged or exhausted by continued effort, so the epithelial cells
of the intestine, which play such an important part in the absorption
of proteid matters from the alimentary tract, may, in the presence
of an excess of proteid matter, become temporarily exhausted, and,
refusing passage to the proteoses and peptone formed by proteolysis,
render possible further hydrolytic cleavage into leucin, tyrosin,
lysatin, etc.; bodies which, by one method or another, can be readily
transformed into urea. At the same time, as already stated, it seems
more than probable that some formation of these amido-acids always
occurs in the intestine, and that these bodies have some specific part
to play in the normal processes of metabolism going on in the body.
The more one studies the processes of nutrition in general, the more
one is impressed with the view that there is a purpose in everything,
and that the formation of even such bodies as leucin and tyrosin may
be connected with hidden processes, the key to which has not yet
been found. We see an analogous case, perhaps, in the action of the
inorganic salts in nutrition, some of which, at least, neither undergo
change themselves nor induce changes in other substances, and yet we
know their presence is indispensable for keeping up the normal rhythm
of the nutritional processes of the body.
ABSORPTION OF THE MAIN PRODUCTS OF PROTEOLYSIS.
Public-domain text, read in full here on John Shaqi.
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