On the mechanism of the physiological action of the catharticsMacCallum, John Bruce
Science
On the mechanism of the physiological action of the cathartics
MacCallum, John Bruce
Laxatives -- Physiological effect
By varying the proportions of LiCl and CaCl_{2} the results may be
somewhat changed. The characteristic contractions may be obtained with
as small a quantity of CaCl_{2} as in a mixture of 50 c.c. m/6 LiCl +
¹⁄₂ c.c. m/6 CaCl_{2}. The movements, however, last only 5-10 minutes
and are less active than in a mixture of 50 LiCl + 5 CaCl_{2}. This
latter mixture seems to be perhaps the most favorable, although almost
equally powerful contractions are obtained with mixtures containing
as much as 10 c.c. CaCl_{2} to 50 c.c. LiCl. When more CaCl_{2} than
this is added the movements usually appear later and last a much
shorter time. With equal parts of LiCl and CaCl_{2} they cease in 15
to 20 minutes, while in a mixture of 5 c.c. LiCl + 50 c.c. CaCl_{2}
the movements appear late and last only 4 or 5 minutes. The loops
in mixtures with relatively much CaCl_{2} come to rest in the shape
characteristic of loops in pure CaCl_{2}. They become shortened and
are found to be straightened out at the end of the experiment. Where
relatively much LiCl is present the loops remain almost their original
length and are usually coiled. This is shown in the following table:--
50 c.c. Li Cl 50 c.c. CaCl_{2}
Time 50 c.c. LiCl + + 50 c.c. CaCl_{2}
5 c.c. CaCl_{2} 5 c.c. LiCl
11:14 Length of loop Length of loop Length of loop Length of loop
10 cm. 10 cm. 10 cm. 10 cm.
11:14 no movements no movements no movements no movements
11:20 no movements very active no movements no movements
movements
11:35 no movements very active movements no movements
movements begin
11:40 no movements very active Movements no movements
movements slow
11:50 no movements very active no movements no movements
movements
12:00 no movements very active no movements no movements
movements
12:05 no movements no movements no movements no movements
12:10 Length about Length about Length about Length about
8 cm. 8 cm. 4 cm. 4 cm.
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