When opium is not taken by the _habitué_ for twenty-four hours, his whole body commences to sag, droop, and become unjointed. The result is precisely like taking the starch out of a well-done-up shirt. The man is as limp as a dish-rag, and as lifeless. He perspires all over,--feels wet and disagreeable. To take opium now is to brace the man right up; it tightens him up like the closing of a draw-string. Such is the effect in the internal man, and it pervades thence the entire system. His mortal machine is screwed up and put in running order. The opium not taken at the expiration of the twenty-four hours, rheumatic pains in the lower limbs soon set in, gradually extending to the arms and back; these grow worse as time passes, and continue to grow worse until they become unendurable. Contemporaneously with the pain, all the secretions of the system, but more notably those of the stomach and bowels, are unloosed like the opening of a flood-gate, and an acrid and fiery diarrhoea sets in, which nothing but opium can check. All the corruption engendered and choked up there for years comes rushing forth in a foul and distempered mass. The pain and diarrhoea continue until the patient is either cured, if he has sufficient will and constitution to withstand the torture, or is compelled by his sufferings to return to opium. During the period of time endured without opium, the body is fiery hot and painfully sensitive to every touch or contact. So exquisite is the sensibility, that to touch a hair of the head or beard, is like the jagging of needles into the body. The mouth continually dreuls, and in some instances is ulcerated and sore. As to eating, it is hardly to be thought of; a mouthful satisfies. Of the suffering hardest to withstand, is the _apparent_ stationary position of time, which arises, I presume, from the rigid, intense condition, and intense sensitiveness, of the whole system, and the hopelessness of the thoughts which march like funeral processions through the mind; this, in connection with the sinking state of the spirits, and the awful aching of the heart, places a man in a predicament which no other earthly suffering can parallel. There is no prospect in life; opium has so transformed the human body, that it no longer has natural feelings; there is no expectancy, no hope, for a different future. The appetite for opium at this time is generally master of the man; it rages like the hunger of a wild beast.