Much of the misconception that has arisen relative to the cause of cheese ripening comes from a confusion of terms. In the ordinary use of the word, ripening or curing of cheese is intended to signify the sum total of all the changes that result in converting the green product as it comes from the press into the edible substance that is known as cured cheese. As previously shown, the most marked chemical transformation that occurs is that which has to do with the peptonization or breaking down of the casein. It is true that under ordinary conditions this decomposition process is also accompanied with the formation of certain flavor-producing substances, more or less aromatic in character; but it by no means follows that these two processes are necessarily due to the same cause. The majority of investigators have failed to consider these two questions of casein decomposition and flavor as independent, or at least as not necessarily related. They are undoubtedly closely bound together, but it will be shown later that the problems are quite different and possibly susceptible of more thorough understanding when considered separately. In the earlier theories of cheese ripening it was thought to be purely a chemical change, but, with the growth of bacteriological science, evidence was forthcoming that seemed to indicate that the activity of organisms entered into the problem. Schaffer[195] showed that if milk was boiled and made into cheese, the casein failed to break down. Adametz[196] added to green cheese various disinfectants, as creolin and thymol, and found that this practically stopped the curing process. From these experiments he drew the conclusion that bacteria must be the cause of the change, because these organisms were killed; but when it is considered that such treatment would also destroy the activity of enzyms as well as vital ferments, it is evident that these experiments were quite indecisive. A determination of the nature of the by-products found in maturing cheese indicates that the general character of the ripening change is a peptonization or digestion of the casein. Until recently the most widely accepted views relating to the cause of this change have been those which ascribed the transformation to the activity of micro-organisms, although concerning the nature of these organisms there has been no unanimity of opinion. The overwhelming development of bacteria in all cheeses naturally gave support to this view; and such experiments as detailed above strengthened the idea that the casein transformation could not occur where these ferment organisms were destroyed. The very nature of the changes produced in the casein signified that to take part in this process any organism must possess the property of dissolving the proteid molecule, casein, and forming therefrom by-products that are most generally found in other digestive or peptonizing changes of this class.