PURGATIVES _with_ DIAPHORETICS. This combination of effects is often useful in practice, but it is desirable that the latter should not be established until the operation of the purgative upon the bowels has subsided. This is accomplished by certain doses of _Tartarized Antimony_ in conjunction with some purgative. The _Pulvis Aloes Compositus_ of our Pharmacopœia produces a somewhat similar effect. DIAPHORETICS _with_ TONICS. How frequently is the practitioner desirous of determining to the skin, and at the same time of supporting the strength of the general system? in the progress of a continued fever we are repeatedly called upon to fulfil such indications. Dr. Bree[260] also observes that “in the exhibition of _Diaphoretics_ the addition of a bitter infusion, or tincture, is frequently proper; for the stomach should be gently excited and strengthened during the use of a diaphoretic draught.” On the other hand, _Tonics_ not unfrequently require the aid of a diaphoretic; for instance, in the cure of _Cynanche maligna_, the use of bark is indicated; but if the skin be hot and dry, it should be accompanied with a diaphoretic. _See Form. 126_. ANTISPASMODICS _with_ TONICS, _or_ NARCOTICS. Under the history of Antispasmodics, (_page 78_) it is stated that there are certain bodies which seem to exert an absolute control over inordinate muscular action, from whatever general cause it may have arisen; in administering such remedies, however, the intelligent practitioner will not overlook the peculiar condition of the system in its relations to the disease; where debility is present, the _Antispasmodic_ will be usefully combined with a _Tonic_; and, in certain morbid states of the nervous system, with a _Narcotic_. ASTRINGENTS _with_ DIAPHORETICS. Dr. Fordyce has observed, that combinations of this kind are often indicated in cases of Diarrhœa, where it is necessary to astringe the vessels of the intestines, and at the same time to relax those of the skin; such an indication, he says, may be fulfilled by exhibiting _Tormentil root_, or any other vegetable astringent, with _Ipecacuan_. ASTRINGENTS _with_ NARCOTICS, and ABSORBENTS. It has been already observed, that in a Diarrhœa, depending upon the influx of acrid fluids into the intestines, there are three modes of treatment by which the malady may be obviated, viz. by a narcotic, _diminishing the irritability of the intestines_; by an astringent, _restraining the serous excretion_; and by an absorbent, _neutralizing the acrid matter_. As the modes of action are not incompatible with each other, they maybe simultaneously established with the greatest advantage. _See Form. 52_.