Pharmacologia: Fourth American, from the Seventh London EditionParis, John Ayrton
Science
Pharmacologia: Fourth American, from the Seventh London Edition
Paris, John Ayrton
Pharmacognosy; Pharmacology; Pharmacy
QUALITIES. A colourless transparent liquid, although it occasionally
exhibits a yellow tinge; _Odour_ like that of bitter almonds; _Taste_
bitterish and peculiar: these properties however are soon lost by
exposure to air and light, and the acid undergoes spontaneous
decomposition. CHEMICAL COMPOSITION. The true nature of _Prussic_ acid
was not ascertained until 1815, when Gay Lussac presented to the Royal
Institute of France, a memoir which at once developed its real chemical
constitution; and it is now admitted to consist of a peculiar gaseous
and highly inflammable compound of carbon and nitrogen, to which the
name _Cyanogene_ has been assigned, and of hydrogen; the latter body
acting as the acidifying principle, whence the term _Hydro-cyanic_ acid
is well contrived to express its composition. The medicinal, or
_diluted_ acid, however, contains but a small proportion of this
concentrated compound; according to M. Majendie, one part of the acid of
Gay Lussac and eight parts and a half of water, by weight, or one part
of acid with six times its volume of water, constitute the preparation
which should be used in medicine; and which, to avoid the possibility of
mistake, ought always to be prescribed as the Acidum Hydro-cyanicum
_dilutum_, and is, in fact, the _Prussic acid_ of Scheele. Dr. Ure, who
has lately taken considerable pains upon this subject, has constructed a
table exhibiting the relations between the specific gravities, and
quantities of real acid, in preparations of different strength; from
these experiments it would appear that an acid of specific gravity 0·996
or 0·997 is such as is usually prescribed in medicine.[342] MEDICAL
USES. In a sufficient dose, hydro-cyanic acid instantly destroys life by
extinguishing the nervous energy of the body;[343] but it has at the
same time been observed that animals submitted to its action would often
continue to breathe for several hours freely, and to circulate their
blood, although no trace of sensibility or muscular contractility could
be found after its application. This remarkable property of
extinguishing the general sensibility, without any ostensible injury to
respiration and circulation, naturally led to a belief that the
hydro-cyanic acid, or prussic acid, might be advantageously used in
cases of excessive sensibility and irritation, particularly when these
two morbid states are likely to affect either the respiratory organs or
the circulation generally. This kind of analogical reasoning, it is
said, induced Professor Brera, ten years ago, to administer it in cases
of high pulmonary and other inflammations, in doses of four drops twice
a day; when, as we are told, the violence of the disease was quickly
subdued. The remedy, however, does not appear to have excited much
attention, until after the first essay of Dr. Majendie, who deserves
whatever credit may belong to its introduction. Seven years of trial
have elapsed, and the general sense of the medical profession with
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