Pharmacologia: Fourth American, from the Seventh London EditionParis, John Ayrton
Science
Pharmacologia: Fourth American, from the Seventh London Edition
Paris, John Ayrton
Pharmacognosy; Pharmacology; Pharmacy
QUALITIES. _Form:_ white, semi-transparent masses, of a striated or
crystalline aspect, which, on exposure to air effloresce; _Odour_,
pungent and peculiar; _Taste_, acrid but cooling. CHEMICAL COMPOSITION.
It will be found to vary materially in its composition according to the
temperature employed for its preparation; the quantity of alkali varying
from 20 to 50 per cent. Mr. Phillips considers the _Sub_-carbonate of
ammonia to be a _Sesque_-carbonate, composed of 3 atoms of carbonic
acid, 2 atoms of ammonia, and 2 of water; or that it is a definite
compound of _Carbonate_ and _Bi-carbonate_, one atom of each, with two
atoms of water; one hundred parts, by experiment, consist, of 54·2
_carb: acid_, 29·3 _Ammonia_, and 16·5 _water_; if we consider it as a
_Sesque-carbonate_, its constitution, according to Dr. Wollaston’s
scale, will be 55·72 _Carbonic Acid_, 29 _Ammonia_, 15·28 _water_.
SOLUBILITY. According to Duncan it is soluble in twice its weight of
cold water; Mr. Phillips states four times; the mean of these will be
found nearly correct. Its solubility however is increased by increase of
temperature, but when dissolved in boiling water it effervesces, and
undergoes a partial decomposition; it is quite insoluble in alcohol, and
hence on the addition of spirit to a strong solution, a dense coagulum
is produced. INCOMPATIBLE SUBSTANCES. It is decomposed by _acids_,
_fixed alkalies_, and their _sub-carbonates_, _lime_, _solution of
muriate of lime_, _magnesia_, _alum_, _super-tartrate of potass_, and
all the _acidulous salts_, _sulphate of magnesia_, _acetate_,
_sub-muriate_, and _oxy-muriate of mercury_, _acetate_, and _sub-acetate
of lead_, and the _sulphates of iron and zinc_. If it be added to
decoctions and infusions they must be previously cooled. FORMS OF
EXHIBITION. Since by exposure to air its virtues are impaired, it ought
not to be kept in powdered mixtures; in the form of pill it is preserved
much longer, especially if it be combined with some vegetable extract.
USES. It is stimulant, antispasmodic, diaphoretic, powerfully antacid,
exceeding in this respect the fixed alkalies, and in large doses it is
emetic. It is highly useful as a stimulant in those gastric affections
which supervene habits of irregularity and debauchery; combined with
opium it affords a powerful resource in protracted diarrhœa attended
with debility of the alimentary canal: and in cases of muscular atony so
frequently witnessed, as the _sequela_ of chronic rheumatism, ammonia,
in large doses, offers the best remedy; I have moreover witnessed the
beneficial effects of this remedy in hoarseness depending upon relaxed
states of the throat. In typhus fever it has been particularly
recommended by Huxham, Pringle, and many other physicians, and some have
considered it superior to any other stimulant upon such occasions. It is
also useful in syncope and hysteria, in the form of smelling salts;[366]
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