As the urinary passages were no-way injured, so neither were the stomach, guts, and other _viscera_ of the lower belly. These had all a healthful appearance, except the gall-bladder, which was almost full of biliary concretions: nor is it surprising, that soap and lime-water, which prevent the growth of urinary _calculi_, should have no effect on biliary stones, since, altho’ these medicines dissolve the former out of the body, yet they do not make the smallest impression on the latter. I presume it will be needless to take notice, that the lingering nervous fever, of which Lord Walpole died, cannot, with any colour of reason, be ascribed to the large use of soap and lime-water; since, if they could have produced such an effect, they must have done it in much less time than eight years and an half. It may not be amiss to observe, that altho’ soap and lime-water, taken in large quantities, are no-way injurious to health, yet in some cases they may become improper, on account of the particular state of the patient. Thus, in a scorbutic or putrid disposition of the humours, soap at least ought to be totally omitted; and such patients, who are much troubled with the hæmorrhoids, ought to be sparing in its use, as the alkaline salt, with which it abounds, will scarcely fail to exasperate their pain. Where the patient is naturally very costive, less lime-water and more soap ought to be used; and, on the contrary, where the body is too loose, little or no soap is to be taken, but the cure is to be trusted to lime-water alone; which, in this case, ought to be drank to the quantity of two English quarts a day. As the foregoing observations will, I am afraid, appear more tedious than important, I shall only add, that I am, with great esteem, +SIR+, Your most obedient humble Servant, Robert Whytt. III. [Read April 21, 1757.] _Dr._ Pringle’s _Paper read after Dr._ Whytt’s _Letter_. DR. Pringle begs leave to inform the Society, that having read the copy of his letter, within these few days, to Dr. Shaw, Mr. Hawkins, and Mr. Graham, those gentlemen found his account agreeable to their several observations; only Mr. Graham took notice, that, of late years, Lord Walpole, in his journies to Norfolk, had twice voided some blood with his urine, but with little uneasiness; and that at other times had passed some sand and stony particles (tho’ never larger than the head of a small pin), attended with frettings of the parts, scarce painful. But Mr. Graham was not sure, whether these accidents were prior or subsequent to the sequel of the case, communicated to the Society by his Lordship.