From the time I began to use the soap, my gravelish symptoms gradually abated; but, upon walking two or three miles, I made bloody urine. However, that symptom gradually abated; and in the year 1743 all the symptoms of a stone quite vanished, insomuch that I could walk, ride, or go in a machine, as well as ever. From February 1739, to July 1743, I took every day five or six drachms of soap: but after that time I diminished the dose to half an ounce; and never after had any return of a gravelish symptom, tho’ I still imagine the stone is not intirely dissolved; for after sitting some time, I find as it were something come to the neck of the bladder, but which gives me no uneasiness. This, Sir, according to the best of my memory, is my case: and if it can be of any benefit to you, in the cure of this painful disease, it will give great pleasure to, Dear Sir, Your most obedient Servant, Matthew Simson. Nov. 20th, 1749. _The Extract from Dr._ Austin’_s Letter to Dr._ Pringle. [Read April 28, 1757.] THE Rev. Mr. Simson’s letter to me as written in the year 1749; about which time he told me, that he had ridden 40 miles in a day, without any bad symptom ensuing. In the year 1752 he broke his thigh-bone at the neck; by a fall from his horse, and continued for six weeks in great pain; but after that time he grew easier, and was able to put his foot to the ground. One day, as his servant was helping him to walk across the room, he let him fall; upon which Mr. Simson felt a severe pain: the broken leg became then evidently shorter than the other; and by that misfortune he was confined to his bed for near two years. However, about six months before he died, he was so well recovered, as to be able to go to church, and to perform divine service. About the beginning of May 1756, Mr. Simson was seized with a diarrhæa, which resisted all medicine, and carried him off in the 83d year of his age. From the date of his letter to his death he had never discontinued the use of the soap (except during the time of his last illness), tho’ he had not been troubled with any painful symptom of a stone since the year 1743. I obtained leave of his friends to open the body, but found no stone or gravel in the bladder; that part appearing to be, in every respect, in a natural state, except at the neck, where the coats seemed to be schirrous, and were about a quarter of an inch thick. It is probable, that the stone had been of a softer texture, and more easily dissolved, than ordinary; otherwise five or six drachms of soap taken daily, even for so long a time, could not have dissolved it intirely; for many have used that medicine in much larger doses, and at the same time have drank lime-water plentifully, without obtaining such effects; tho’ all their painful symptoms were removed by that course, as Dr. Whytt has shewn in his treatise on this subject.