On the 28th of June 1757. Mary Alexander, aged 31 years, of the parish of Whitechapel, was brought into the London hospital, having a mortification in both hands, which reached about an inch and half above the wrists. All her toes, and about an inch of one foot beyond the last joint, were mortified; her nose was also intirely destroyed by a mortification; and all these happened at the same time. Upon inquiry into the cause of this misfortune, I found, that on Monday the 30th of May she was seized with a quotidian ague, which usually began about three of the clock in the afternoon, and lasted near two hours; which was succeeded by a hot fit, and then a violent sweat. And in this manner she was afflicted for seven days without any material alteration; when, being informed by a neighbour, of a person, who had an infallible remedy for the cure of an ague, she applied to him. He brought her two phials, containing about an ounce and half each, of a pale yellowish liquor; one of which he directed her to take directly, promising, that she should have no return of the fit of consequence; and that, if she had any small return, the second bottle should cure her effectually. In consequence of which, she took one dose, which was at the time the cold fit had been on about a quarter of an hour: she had no sooner swallowed it, but, as she says, her stomach was on fire, and felt as if she had swallowed the strongest dram possible. The cold fit left her instantly; but she was immediately seized with so violent a fever, as to make her burn, and be extremely thirsty, all the following night; much more so than ever she had been before, till the next morning, when a sweat a little relieved her from the violent heat. When she rose in the morning, she was much troubled with a great itching in the hands, feet, and nose; and soon after all those parts began to feel numbed, or, as she describes it, as if her hands and feet were asleep; which she took but little notice of, till the evening of that day, when she found the nails of both hands and feet were turning black, and, at the same time feeling great pain in both, as also in her nose, and that they appeared of a darkish red colour, like the skin in cold weather. Upon which, at nine o’clock that night she sent for an apothecary, from whom, I have since been informed, the person before mentioned had bought the medicine, which he gave her. The apothecary was not at home; his journeyman went, and finding the woman had a difficulty of breathing, ordered her a mixture with sperma ceti and ammoniacum to be taken occasionally. The apothecary did not see her himself till the 16th of June, when finding her in a very bad condition, that her hands, and feet, and nose, were intirely black, and had many vesicles or small bladders upon them, filled with a blackish bloody water; he opened them, and let out the fluid, and dressed them with yellow basilicon; and in this manner continued treating her till