He found the tumors in her right breast much enlarged, and so connected together, as to feel like one large one only. On the upper part of the breast, upon the pectoral muscle, it felt rugged, unequal, and almost as hard as a stone. The patient complained of a constant itching in the part, and at times a pungent pain, which seemed to shoot from the armpit, and end in the tumor. Under this armpit the glands were hard and schirrous; and the left breast was not exempt from the like indurations. A vein or two on the right breast was a little enlarged, otherwise no alteration. It was no hotter than common; nor had it undergone any change of colour. To mitigate the pain of the schirrous, Dr. Lambergen ordered the following plaister: ℞ _Ung. Diapomphol._ ℥ ij. _Amalgam, merc. et Plumb._ ȝ iij. _Sperm. Cet._ ȝ j. _M._ With this external application he prescribed likewise the following powders, to be taken night and morning, and gave directions relating to the non-naturals. ℞ _Coral. rub. Antimon. Diaphoret. illot. Sper. Ceti a_ ȝ ij. _Laud. gr._ vj. _M._ for 12 doses. Under this method the pain remitted, but the tumor inlarged, and a little rising was observed on the upper part of it; and towards the nipple, where there was the least hardness, a small spot was perceived, which, at the next return of the catamenia, inflamed, and became the seat of the most excruciating pain. Dr. Lambergen, during this period, in the room of the powders, substituted emmenagogic pills, and ordered the pediluvium. She lost ten ounces of blood from the foot: and by these means the swelling of the breast diminished, and the patient suffered very little for some days. This truce, however, was but temporary: the rising on the upper part of the tumor began to inflame, itched intolerably, the pain returned, was almost perpetual, and insupportably pungent. In this dreadful state was the patient, when Dr. Lambergen desired the late Dr. du Bois, Dr. Winter, physician to the house of Orange and professor at Leyden, together with Dr. Van Arum of Leewarden, physician in ordinary to the Princess dowager, to visit her. These gentlemen examined her many times, and unanimously agreed, that it was now no less than a confirmed cancer. It was Professor Winter, who acquainted Dr. Lambergen, that he had heard M. Degner, a celebrated physician at Nimeguen, speak of the Bella-donna, as a sovereign remedy against inveterate schirri; adding, nevertheless, that he had never tried it himself.