In such a case as this, where death seemed inevitable, a dangerous remedy is to be preferred to none at all. Dr. Lambergen therefore determined to try it upon his patient; but, knowing the character, which the plant bore, he resolved to try the effects of it upon himself first. To this end, he poured ten tea-cups of water upon a scruple of the leaves, which had been gathered and dried three years: he let it stand all night lukewarm. Of this infusion he took half a tea-cup full, being the twentieth part of the whole, in the morning fasting; but perceived no effect from it. This determined him the next morning to double the dose; which produced a slight vertigo, and for an hour or two an uncommon dryness in his mouth. Being thus prepared, as he knew his patient had but a weak nervous system, he determined to begin with caution. It was the 14th day of January 1745, that she took the first dose, being one tea-cup full. It had the same effect upon her, as it had had on her physician; and moreover rendered her pulse weaker and quicker than usual. For seven mornings successively she took the same dose, which, in general, produced the same effect. At the same time the plaster was renewed, with the addition of a few grains of opium. Under this method her pain was mitigated; but, before the latter end of the week, returned again more frequently, and more acute; so that she was reduced to a most deplorable condition. The rising on the upper part of the breast became livid; the place near the nipple before-mentioned inflamed, and was very painful; and two little pointed risings were observed upon it, together with a slight fissure or opening. As the menstrual period was approaching, the infusion and the powders were omitted, and the pediluvium substituted. A mixture with crabs-eyes, spᵗ. nitri. d. and syr. e mecon. relieved the patient from some spasmodic complaints she had at this time, and the menses returned more copiously than ever. The 27th she took something more than a tea-cup of the infusion, being the first dose of the second scruple: her body was soluble; her breast less swelled, but the pain returned very acute, and seemed to terminate in the little callous eminence on the upper part of the breast, which now likewise became more pointed. The 28th she took the same quantity of the infusion. The two little pointed places near the nipple were now become two little holes, but had not discharged any matter. The other sore on the upper part of the breast was more livid still, and more painful, and had risen into two little whitish points. The powders were omitted this night, as they had been now and then at other times. The 29th, very little sleep the foregoing night, great pain from the upper sore, the holes near the nipple were become larger, and had run a yellowish matter. The same dose of the infusion as before. At night she had most acute pain from the upper sore. The 30th both sores were nearly in the same state. All remedies were this day