Mr. Mountaine justly observes, “that my rule does not admit of a zone containing N. and S. latitudes.” But the remedy is, _to extend the lesser latitudes to an equality with the greater; that the cone may be changed into a cylinder, and the rumbs into straight lines_. LXXV. _Cases of the remarkable Effects of Blisters in lessening the Quickness of the Pulse in Coughs, attended with Infarction of the Lungs and Fever: By_ Robert Whytt, _M. D. F.R.S. Fellow of the Royal College of Physicians, and Professor of Medicine in the University of_ Edinburgh. [Read Feb. 16, 1758.] ONE of the most natural effects of blistering plaisters, when applied to the human body, is to quicken the pulse, and increase the force of the circulation. This effect they produce, not only by means of the pain and inflammation they raise in the parts to which they are applied, but also because the finer particles of the _cantharides_, which enter the blood, render it more apt to stimulate the heart and vascular system. The apprehension, that blisters must in every case accelerate the motion of the blood, seems to have been the reason, why some eminent physicians have been unwilling to use them in feverish and inflammatory disorders, till after the force of the disease was a good deal abated, and the pulse beginning to sink. However, an attentive observation of the effects, which follow the application of blisters in those diseases, will shew, that instead of increasing, they often remarkably lessen the frequency of the pulse. This I had occasion formerly to take notice of[31], and shall now evince more fully by the following cases.