I agree intirely with you, as to the use of blisters in fevers; being of opinion, that when there is no particular part obstructed or inflamed, they are of little service, and sometimes hurtful, unless perhaps towards the end, when the pulse begins to sink. Nay, in fevers, where the substance of the brain is affected, and not its membranes, I have never found any sensible benefit from blisters: and I always suspect the brain itself affected, when a fever and delirium come on without any preceding head-ach, or redness in the _tunica albuginea_ of the eyes. This kind of fever I have met with several times, and have observed it to be generally fatal. LXXVI. _A remarkable Instance of Four rough Stones, that were discovered in an human urinary Bladder, contrary to the received Opinion; and successfully extracted by the lateral Method of Cutting for the Stone. By Mr._ Joseph Warner, _F. R. S. and Surgeon to_ Guy’s-Hospital. [Read Feb. 23, 1758.] THE favourable reception those few papers have met with from the Royal Society, which I have done myself the honour of addressing to them, encourages me to take the liberty of offering the following account to their consideration: and I am the more immediately induced to submit this paper to their perusal, as the fact hereafter related may possibly be not esteemed a matter of mere curiosity; since it is probable, that the inferences deduced from the history of the subsequent case, when attended to, may prove of the greatest consequence to the future ease and welfare of the patient, as well as be a means of preventing the operator from falling into such errors, as cannot fail of drawing an imputation upon his character, in the practice of one of the most capital and difficult undertakings in his profession. It is a maxim laid down by the most judicious and best received writers upon operations in surgery, that when the surface of a stone, which has been extracted from the bladder, appears to be totally rough, it amounts to a proof of its having been there alone. But notwithstanding I admit it is from experience found, that the observation is in general well grounded, it may nevertheless appear, from the following case, that this rule is not unexceptionable: for which reason perhaps it may be thought right, that we should not be determined from circumstances only; but, on the contrary, that it is necessary for every surgeon to take such methods during the operation, as will enable him to judge with that degree of certainty, without which he cannot be enabled to do so.