was some reason to suspect, and indeed to hope, that tho’ the pulse had been perfectly calm during the whole time of the delirium, there was something of the fever still at the bottom of this complaint. From these indications, obscure as they were, it was judged proper to make a trial of the bark; which was accordingly ordered to be taken immediately, and to be repeated every two hours. This method succeeded beyond what could have been imagined; insomuch that it was observable, even by the attendants on this gentleman, that his mind came evidently more and more to itself after every dose: and in the evening, after he had taken six drachms, his urine grew thick, and dropt a lateritious sediment; and, excepting the weakness naturally consequent on such violent emotions as he had undergone, both of mind and body, he was as well as ever he had been in his life. He hath repeated the bark at proper intervals, as is usual after intermittent fevers, and continues to this day perfectly well. The use of the bark, in the most irregular intermittent disorders, is very happily so well known in this island, that it might perhaps have been thought needless to have recited any case merely in confirmation of this practice: and I am too well aware of the insufficiency of every thing, but a number of facts on which to found any philosophical truth, to presume to rest any thing on one single instance only. But the case above related is of so very extraordinary a kind, as to make it worthy of being mentioned, both on its own account, and for that analogy, which being found by experience to subsist between diseases, affords the surest method of reasoning on practical subjects. The two remarkable circumstances of this case are, the delirium’s coming on, and continuing, without any exacerbation of the pulse; and the bark’s proving so speedy and effectual a remedy, tho’ given at a time, when there was no appearance of any remission of the symptom, which it was intended to remove. It hath been thought, that a quick pulse is so essential to the definition of a fever, as to be a pathognomonic symptom of it. But experience is against this notion: perhaps the present case is a proof of the contrary; however this be, there have not been wanting instances, in which, towards the end of a fever, the pulse has grown quiet, without the abatement of any other symptom, and the patient hath generally lain comatose, and with the appearance of one, who hath taken a large quantity of opium. Galen, in the third book of the Presages of the Pulse, mentions this symptom, and pronounces it to be almost a fatal sign: and the same thing hath happened in more instances than one, which have come to my knowlege. May not then the above-recited case lead to this useful inquiry, Whether in fevers of every kind, when the pulse is quiet, the bark is not proper to be given, and likely to prove a remedy? In this case it proved absolutely