After satisfying myself with this result respecting the veins, I thought I would ascertain if the arteries exhibited analogous properties. These vessels are in a less favourable condition; their texture is less spongy than that of the veins and with an equal caliber, their parietes are much thicker. It was easy then to foresee, that if the phenomenon of absorption showed itself, it would appear much slower than in the veins; this was confirmed in an experiment on two large rabbits, in whom I dissected perfectly clean one of the carotid arteries. It was more than a quarter of an hour before the solution of nux vomica passed through the parietes of the artery. As soon as I saw the symptoms of poisoning distinctly, I stopped moistening the vessel; yet one of the rabbits died. In order then to convince myself that the poison had really passed through the arterial parietes, and that it had not been absorbed by small veins which might have escaped my dissection, I carefully detached the vessel that had been used in the experiment; I cut it open in its whole extent, and I made those who assisted me taste a little of the blood, that was still adhering to the internal surface; they all perceived in it, and I did myself, the extreme bitterness of the extract of the nux vomica. To these experiments may be objected a fact that is observed, which is, that absorption does not take place the same under all circumstances; its activity is redoubled or diminished, according to the state of some other functions. Thus during a paroxysm of fever, a medicine, which would usually act with great effect, often produces, when given in a double or treble dose, no perceptible effect. Now if absorption, was a purely mechanical phenomenon, would it undergo modifications in relation with those of the vital functions? Without doubt it would; for these modifications of the functions may introduce new physical circumstances favourable or injurious to the production of a mechanical phenomenon. Thus in the present case, the state of fever, by accelerating the circulation distends with blood the arteries and the veins. The fluid that is to be absorbed must pass from the exterior to the interior of these vessels. Now it may be easily conceived, that the quantity of blood which they contain must have a great influence upon the production of the phenomenon by the greater or less degree of tension of their parietes. This is moreover completely confirmed by experiment.