I opened the abdomen of a dog, and having brought the stomach out at the opening, I tied with care the vessels that went to this viscus, and I removed the whole of it (I ascertained in some of the preceding experiments that a dog can live eight and forty hours after his stomach has been removed.) I made a suture in the abdominal parietes; then, having laid bare the crural vein, I injected into its cavity a solution of two grains of emetic in an ounce and a half of water. I had hardly finished the injection when the dog began to have nausea, and he soon made all the efforts that an animal does when he vomits. These efforts appeared to me to be even more violent and longer continued than in ordinary vomiting. The dog remained quiet about a quarter of an hour; I then renewed the injection, and I forced two grains more of emetic into the crural vein; this was followed with the same efforts of vomiting. I repeated the experiment many times and always with the same success; but this experiment suggested to me another, which I performed in the following way: I took a dog of good size, from whom I removed the stomach, as I had done in the preceding experiment; I introduced into the abdomen a hog’s bladder, to the neck of which I had fixed, by threads, a canula of gum elastic; I put the end of this canula into the extremity of the œsophagus, and I fixed it there also by threads, so that the bladder resembled somewhat the stomach, and was, like it, in communication with the œsophagus. I introduced into the bladder about a pint of common water; this distended it, but did not fill it completely. A suture was made in the wound of the abdomen, and four grains of emetic were injected into the jugular vein. Nausea soon appeared, and was followed with real efforts of vomiting; finally, after some minutes, the animal vomited up abundantly the water from the bladder. It followed evidently from the preceding experiments, that the abdominal muscles and the diaphragm concurred to produce vomiting; but it remained to be ascertained, what was the part of the diaphragm in the production of this phenomenon, and what was that of the abdominal muscles.