*Nerve Stimuli.*—While the properties of irritability and conductivity supply a necessary cause for the production and transmission of nervous impulses, these alone are not sufficient to account for their origin. An additional cause is necessary—a force not found in the nerve protoplasm, but one which, by its action on the protoplasm, makes it produce the impulse. In this respect, the neuron does not differ essentially from the cell of a muscle. Just as the muscle cell requires a stimulus to make it contract, so does the neuron require a stimulus to start the impulse. Hence, in accounting for the activities of the body, it is not sufficient to say they are caused by nervous impulses. We must also investigate the _nerve stimuli_—the means through which the nervous impulses are started. Most of these are found outside of the body and are known as external stimuli. *Action of External Stimuli.*—In the arrangement of the nervous system the most favorable conditions are provided for the reception of external stimuli. Not only do vast numbers of neurons terminate at the surface of the body,(104) but they connect there with delicate structures, called _sense organs_. The purpose of the sense organs is to _sensitize_ (make sensitive) the terminations of the neurons. This they do by supplying special structures through which the stimuli can act to the best advantage upon the nerve endings. Moreover, there are different kinds of sense organs, and these cause the neurons to be sensitive to different kinds of stimuli. Acting through the sense organs adapted for receiving them, light, sound, heat, cold, and odors all act as stimuli for starting impulses. Indeed, the arrangement is so complete that the nervous system is subjected to the action of external stimuli in some form practically all the time. The work of the sense organs is further considered in Chapters XX, XXI, and XXII. *How External Stimuli act on Internal Organs.*—For stimulating the neurons not connected with the body surface we are dependent, so far as known, upon the nervous impulses. An impulse started by the external stimulus goes only so far as its neuron extends. But it serves as a stimulus for the neuron with which the first connects and starts an impulse in this connecting neuron, the point of stimulation being where the fiber terminations of the first neuron make connection with the dendrites of the second. This impulse in turn stimulates the next neuron, and so on, producing a series of impulses along a given nerve path. In this way the effect of an external stimulus may reach and bring about action in any part of the body. This is in brief the general plan of inducing action in the various organs of the body. This plan, however, is varied according to circumstances, and at least three well-defined forms of action are easily made out. These are known as _reflex action, voluntary action_, and _secondary reflex action_.