By far the worst form of venereal disease is _syphilis_, a malady which was formerly confounded with the two forms of disease mentioned, but from which it is essentially different. At first, a very slight local lesion, of no more consequence--except from its significance--than a small boil, it rapidly infects the general system, poisoning the whole body, and liable forever after to develop itself in any one or more of its protean forms. The most loathsome sight upon which a human eye can rest is a victim of this disease who presents it well developed in its later stages. In the large Charity Hospital upon Blackwell's Island, near New York City, we have seen scores of these unfortunates of both sexes, exhibiting the horrid disease in all its phases. To describe them would be to place before our readers a picture too revolting for these pages. No pen can portray the woebegone faces, the hopeless air, of these degraded sufferers whose repentance has come, alas! too late. No words can convey an adequate idea of their sufferings. What remorse and useless regrets add to the misery of their wretched existence as they daily watch the progress of a malignant ulceration which is destroying their organs of speech, or burrowing deep into the recesses of the skull, penetrating even to the brain itself! Even the bones become rottenness; foul running sores appear on different portions of the body, and may even cover it entirely. Perhaps the nose, or the tongue, or the lips, or an eye, or some other prominent organ, is lost. Still the miserable sufferer lingers on, life serving only to prolong the torture. To many of them, death would be a grateful release, even with the fires of retributive justice before their eyes; for hell itself could scarcely be more awful punishment than that which they daily endure. Thousands of Victims.--The venturesome youth need not attempt to calm his fears by thinking that these are only exceptional cases, for this is not the truth. In any city, one who has an experienced eye can scarcely walk a dozen blocks on busy streets without encountering the woeful effects of sexual transgression. Neither do these results come only from long-continued violations of the laws of chastity. The very first departure from virtue may occasion all the worst effects possible. Effects of Vice Ineradicable.--Another fearful feature of this terrible disease is that when once it invades the system its eradication is impossible. No drug, no chemical, can antidote its virulent poison or drive it from the system. Various means may smother it, possibly for a life-time; but yet it is not cured, and the patient is never safe from a new outbreak. Prof. Bumstead, an acknowledged authority on this subject, after observing the disease for many years, says that "he never after treatment, however prolonged, promises immunity for the future."[44] Dr. Van Buren, professor of surgery at Bellevue Hospital Medical College, New York, bears the same testimony.