16. The difficulty of procuring paraffin at the proper melting point. 17. Hypersensitiveness of the skin over the injected area. 18. Redness of the skin over the injected area. To those the author would add: 19. Secondary diffusion of the injected mass. 20. Hyperplasia of the connective tissue following the organization of the injected matter. 21. A yellow appearance and thickening of the skin after organization of the injected mass. 22. The breaking down of tissue and the resulting abscess due to the pressure of the injected mass upon the adjacent tissue after the injection has become organized. Each of the above subdivisions may be advantageously considered individually, to wit: =1. Intoxication.=—The danger of intoxication may truly be said to be more so due to the unclean or unsterilized matter injected than to the absorption following its employment, although Meyer has claimed untoward symptoms found in his experiments from absorption of injections of vaselin in the animal. Taddie and Delain, Stubenrath, Straume, Sobieranski, and Dunbar have corroborated this claim. They injected paraffin of various melting points in the lower animals and observed results therefrom, among which were loss of hair, a reduction of eighteen per cent in the body weight in two months and death. Stein and Harmon Smith refute these conditions and remarked neither systemic nor local untoward results from such injections when paraffin of higher melting points were used. Jukuff claims that no toxic symptoms resulting from the absorption of paraffin injected into tissues are shown, unless the amount be equal to ten per cent of the weight of the animal. To have this apply to the human as much as ten to fifteen pounds would have to be injected—an amount never required in operations of this nature. While it cannot be denied that the injected mass becomes more or less absorbed in from two to three months and is replaced by connective tissue, it may be definitely stated that no toxic symptoms are caused directly thereby, except by the employment of an impure product. =2. Reaction.=—The reaction following a properly made injection is of a mild inflammatory character. Considerable inflammation points to some fault in the technique or impurity of the injection. More or less edema of the site and its adjacent area may be noted, associated with slight or marked discoloration and pain of variable degree. The normal reaction following the injection is temporary and does not necessitate treatment or confinement of the patient, who can resume the duties of life fifteen hours after the operation. =3. Infection.=—The cause of infection cannot be said to be due to anything but surgical uncleanliness, as it is with any surgical undertaking, and can be overcome by the same means.