The notorious La Bosse left on record her method of preparing the "poisoned shirt." The garment was first to be washed, and the tail then soaked in a strong solution of arsenic, so that it only looked "a little rusty," as if it had been ill-washed and was stiffer than usual. "The effect," she concludes, "it should produce on the wearer is a violent inflammation and intense pain, and that when one came to examine him, one would not detect anything." The Duke of Savoy is said to have succumbed to the effects of a poisoned shirt of this kind. Some time ago Dr. Nass, a French medical man, made some interesting experiments, with a view to testing the truth of these stories. He carefully shaved a portion of the left lumbar region of a guinea-pig, and gently rubbed the skin with a paste containing arsenic, in the proportion of one in ten. He repeated this operation several times during the day. Shortly afterwards the animal became prostrate, the eyes became dull, it assumed a cholera-like aspect, and in forty-eight hours died. The skin on which the paste had been applied remained unchanged and unbroken, and showed no sign of ulceration. On examining the internal organs after death, fatty degeneration of the viscera was found, as is usual after arsenical poisoning. This experiment does not, of course, actually prove the effect of a shirt impregnated with arsenic being worn in direct contact with the skin, but it shows that arsenic may be introduced into the body by simple, gentle friction on an unbroken skin, and that the poisoned shirt theory was possible. The administration of poison in the form of medicine is another method which has often been criminally employed. In France, the enema was at one time frequently made use of for introducing arsenic, corrosive sublimate, and opium into the system. The poisoner's aim, in such cases, was to attribute the fatal effects which followed to disease. Within recent years a curious case was tried at the Paris Court of Assizes, in which a lady was charged with attempting to poison her husband. It was known that the couple had lived unhappily together, and arrangements had been made for a divorce. One morning the husband complained of a severe headache, and his wife suggested a dose of antipyrine, which she gave him in some mineral water. He remarked to her at the time that the draught had a peculiar taste. Later in the day she administered sundry cups of coffee to him; but he grew rapidly worse and at night a doctor was summoned. He failed to diagnose the complaint, and called in other medical men, who were equally puzzled. One thing which they all noticed, was a peculiar dilation of the pupils of the patient's eyes. A consultation was held the next day, and shortly afterwards one of the medical men received a note from the lady, in which she stated, that her husband "was black. He was dead, more dead than any man I ever saw."