When the pimple appears on the outside of the prepuce for instance, it assumes generally a larger form, and, as the head is broken off, crust after crust rises up, until the process of ulceration has very far advanced, or the applications that are generally employed prevent its re-formation. In the former instance, the crusts are attributable to evaporation of the discharge; in the latter, their absence is already explained by the prevention of the same. There is such a thing as sympathy in eruptive disorders. In skin affections of the corners of the mouths of children, we often see the inflammation cross from corner to corner. The same is observable where the attacks comprise the angle of an eye. So is it with the penis, a structure equally as delicate; and accordingly the edges of the prepuce often put on a jagged appearance resembling chaps on hands. [Illustration] Witness the above wood-cut. It portrays an ulcer somewhat diffused on the prepuce, and the ragged edge of the same structure. The sketch just introduced was taken from a patient perhaps only a fortnight old with the disease. Being a rackety, dissipated young man, and regardless of the treatment suggested, a week’s neglect produced the following alteration:— [Illustration] A new ulcer sprung up, the old one increased in size, and the entire edge of the prepuce became involved in the irritation. Phymosis and paraphymosis occur in syphilis as they do in gonorrhœa. The treatment is the same in both. Warm, soothing applications are indispensable; and occasionally, to prevent adherence between the glans and prepuce, the scalpel must be had recourse to. I have already expressed my conviction that the progress of the disease rests as _much_ or _more_ upon the condition of the party receiving it, than the specific property of the complaint. “If the inflammation spreads fast and considerably, it shows a constitution more disposed to inflammation than natural; if the pain is great, it shows a strong disposition to irritation. It also sometimes happens that they begin very early to form sloughs; when this is the case, they have a strong tendency to mortification. Bleeding is also a consequence owing to exposure of the ulcered _corpus cavernosum_.”—_Hunter._ The reader will recollect that it has been stated that chancres, like the many symptoms of gonorrhœa, differ in their characteristics. Quoting from authorities, and, as will be further illustrated, the following may be taken as the summary of the most prominent appearances:—