I have witnessed the sloughing, or, in other words, the loss of the entire top of the glans and prepuce, within half a dozen days. The subjoined drawing (overleaf) represents a tumefied state of the penis, ulceration on the glans surrounding the orifice of the urethra, phymosis of the prepuce, and ulcers in different stages on the outside thereof. The sketch was taken from Wallace’s work. Such are often met with. Chancres, as before stated, often become irritable, spread rapidly, and slough, more particularly in persons of intemperate and dissipated habits, or when the case has been improperly treated; and openings into the urethra are formed to a considerable extent, sometimes to the destruction of the glans, or a portion of the penis. [Illustration] The illustrative companion to this paragraph exhibits an ulcer that has wormed its way through the prepuce, as marked by the black line. [Illustration] Warts are often met with, as in gonorrhœa, and, like those, will arise from simple local irritation, from the accumulation of the natural secretions, or want of cleanliness. They are hard and soft, and require different treatment accordingly. They are not contagious; that is, they do not communicate a venereal affection, but they very readily produce a similar disease in parts they come in contact with. The story is here well told by the engraver’s aid. [Illustration] It often happens that the ulceration appears checked. A tumor (see next page) will form, and the surface will look very red and angry—will even yield a moisture, and finally disappear. I say finally, because it frequently proves very obstinate, and trespasses upon the patience and forbearance almost to induce despair. It usually is very irritable, the itching being most troublesome. The illustration was taken from a patient who had been an invalid several months. [Illustration: _a_—The tumor.] After a certain time, varying in proportion to the virulence of the disease, the poison is conveyed by the numerous absorbents (which run from the penis) to the glands in the groin, one or more of which become inflamed and enlarged, producing that well-known swelling, already alluded to, called _bubo_. Ulcers, too, are sometimes situated within the urethra, as is seen in the annexed cut. [Illustration] OF BUBOES.