=Alcohol.= In concentrated solutions coagulates albumin and has
a corrosive action on mucous membranes. The ingestion of large
amounts causes asphyxia, gastro-enteritis, cloudy swelling of
ganglion cells of brain, and parenchymatous degeneration of kidney
and liver. Lungs, liver, brain and stomach may give an alcoholic
odor. In chronic alcoholism there may be chronic atrophic or
hypertrophic gastritis, atrophic cirrhosis, sclerosis of arteries,
miliary aneurisms of pial vessels, fatty degeneration of heart and
liver, and “hog-back kidney.”
=Alkalies.= Mucosa of mouth and œsophagus swollen and red, with
desquamation of epithelium; mucosa of stomach swollen, dark brown
and ecchymotic, with diphtheritic patches; croupous bronchitis
may result from aspiration of caustic soda or potash, and
bronchopneumonia from inhalation of ammonia. Stricture of the
œsophagus, due to contraction of scar-tissue, may occur when the
patient survives the immediate effects of the poison.
=Antimony.= In acute cases the mucosa of mouth, œsophagus and
stomach is inflamed, with erosions and ulcerations; in chronic
cases there is marked emaciation.
=Arsenic.= Mucosa of stomach œdematous, hyperæmic and ecchymotic;
over the hæmorrhages there may be grayish-white sloughs or
erosions. In these there may be found granules or crystals of the
poison. The glands of the mucosa show cloudy swelling and fatty
degeneration. Yellow sulphide of arsenic may be seen on the gastric
mucosa. The small intestine is filled with a rice-water-like
fluid, as in cholera, and the mucosa is congested, swollen
and hæmorrhagic; the lymphoid tissue may be swollen. There is
slight icterus, cloudy swelling of all organs and ecchymoses in
pericardium and pleura. In chronic poisoning with dilute solutions
characteristic gastro-intestinal changes are wanting. In cases of
suspected arsenic poisoning it is important to take portions of all
organs and tissues for chemical examination.
=Atropine.= Death from asphyxia, resembles heat-exhaustion.
=Chloral-hydrate.= Hyperæmia of lungs, brain and cord. Examine
urine.
=Chloroform.= Fatty degeneration of liver and heart. In delayed
poisoning the liver shows picture of acute yellow atrophy, with
marked icterus, widespread ecchymoses, cloudy swelling of kidneys
and fatty degeneration of heart. Lungs, brain and liver may or may
not give odor of chloroform.
=Ergot.= Sclerosis and contraction of arteries; gangrene of
endometrium; in chronic cases sclerosis of the posterior columns of
the cord.
=Formalin.= Corrosive action on mucosa of stomach; formic-acid in
urine.
=Hydrocyanic Acid and Potassium Cyanide.= The mucosa of stomach is
deep red, swollen, softened and sometimes translucent; soapy to the
touch; odor of bitter almonds or ammonia; blood is fluid, dark or
light cherry-red; red hypostasis.
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