In the summer of 1848, General Wilson purchased the "Boston Republican" a free-soil newspaper, which he edited from January, 1849, to January, 1851, during which two years he gave his whole time to the free-soil cause, and spent more than seven thousand dollars of his own property, in the support of the newspaper, whose continued existence was deemed essential to the welfare of the party of which it was the organ. In 1849, he was chosen chairman of the Free-soil State Committee, in which capacity he acted for four years. In the fall of 1849, a coalition was formed between the free-soilers, and the Democrats of Middlesex County, for the election of senators, and General Wilson was pressed by both parties to stand as a candidate for the Senate, which he steadfastly refused to do. He was, however, in that year, chosen a representative from the town of Natick. When the legislature met, he was unanimously nominated by the free-soilers, as their candidate for Speaker. During the session, he was in his seat every day, always attentive to business. After Mr. Webster made his seventh of March speech, an effort was made to instruct him to vote for the doctrines embodied in the resolutions pending before the legislature; but the proposition was resisted, and voted down by the Whig majority. General Wilson told the House that the people would repudiate that speech, and the men who indorsed it, and that at the coming election, the men who had deserted the cause of freedom would be crushed by the people. This prediction, which was received with defiance by the Whig leaders, was fulfilled, and no one in Massachusetts contributed more to its fulfillment than the man who made it. In the summer of 1850, General Wilson called together, at the Adams House in Boston, the State Committee, and the leading men of the free-soil party, to the number of about seventy. He stated to the meeting that the people would make a coalition; that it would be successful if the committee would aid it; that Mr. Webster's seventh of March speech could be rebuked; the Fillmore administration condemned; a free-soiler sent to the United States Senate in place of Mr. Webster for the long term; and an anti-compromise Democrat for the short term; and in short, that by a coalition, Massachusetts could be placed in such a position that the anti-slavery men could control her policy. After a debate of five hours, in which Messrs. Marcus Morton, Samuel Hoar, J. G. Palfrey, C. F. Adams, R. H. Dana, Jr., and others took part, the meeting declined to sanction the coalition, only nine gentlemen, and they the youngest present, advocating the coalition. The people, however, made it, in spite of the disapprobation of the eminent men, and the State was carried against the Whigs, and Geo. S. Boutwell made Governor, and Charles Sumner and Robert Rantoul sent to the United States Senate.