The glands of the neck, in their efforts to arrest and neutralize the poison, become swollen and sore to the touch, the breath becomes foul from the breaking down of the membrane in the throat, the pulse becomes rapid and weak from the effect of the poison upon the heart, and the dreaded picture of the disease rapidly develops. This process in from sixty to eighty per cent of cases will continue for from three to seven days, when a check will come and the condition will gradually improve. This is a sign that the defensive tissues of the body have succeeded in rallying their forces against the attack, and have poured out sufficient amounts of their natural antitoxin to neutralize the poisons poured in by the invaders. The membrane begins to break down and peel off the throat, the temperature goes down, the headache disappears, the swelling in the glands of the neck may either subside or go on to suppuration and rupture, but within another week the child is fairly on the way to recovery. Should the invaders, however, have secured a foothold in the larynx, then the picture is sadly different. The child may have even less headache, temperature, and general sense of illness; but he begins to cough, and the cough has a ringing, brassy sound. Within forty-eight, or even twenty-four, hours he begins to have difficulty in respiration. This rapidly increases as the delicate tissues of the larynx swell under the attack of the poison, and the very membrane which is created in an attempt at defense becomes the body's own undoing by increasing the blocking of the air-passages. The difficulty of breathing becomes greater and greater, until the little victim tosses continually from side to side in one constant, agonizing struggle for breath. After a time, however, the accumulation of carbon dioxide in the blood produces its merciful narcotic effect, and the struggles cease. The breathing becomes shallower and shallower, the lips become first blue, then ashy pale, and the little torch of life goes out with a flicker. This was what we had to expect, in spite of our utmost effort, in from seventy to ninety per cent of these laryngeal cases, before the days of the blessed antitoxin. Now we actually reverse these percentages, prevent the vast majority of cases from developing serious laryngeal symptoms at all, and save from seventy to eighty per cent of those who do.