Before the appearance of Wille's criticisms Wettstein[9] made a favourable reference to Schübeler's work, accepting his conclusion. He states also that he has himself made analogous experiments with flax, finding that the length of the period of development and a series of morphological characters show an adaptation to local conditions, and that on transference of seed to other conditions the previous effects are maintained. No details, however, are given, and I do not know if anything more on the subject has appeared since. The other examples cited by Wettstein, such as the observations of Cieslar on forest-trees and those of Jakowatz on gentians seem to me open to all the usual objections applicable to evidence of this kind. Such work, to be of any value for the purpose to which it is applied, must be preceded by a study of the normal heredity and of the variations of the species. Most of the recent writers (Semon, Przibram, etc.) on the inheritance of acquired characters accept the story of Brown-Séquard's guinea pigs, which are said to have inherited a liability to peculiar epileptiform attacks induced in their parents by various nervous lesions. The question has been often debated and several observers have repeated the experiments with varying results, some failing to confirm Brown-Séquard, others finding evidence which in various degrees supported his conclusions. Recently a new and especially valuable paper has been published by Mr. T. Graham Brown[10] which goes far towards settling this outstanding question. He states that "the Brown-Séquard phenomenon is nothing more or less than a specific instance of the scratch-reflex," and it is due to a raised excitability of the mechanism of this reflex. This raised excitability is the character acquired as a consequence, for instance, of the removal of part of one great sciatic nerve. The nature of this raised excitability and its causation are discussed and elucidated, but this part of the work is not essential to the present consideration. Mr. Graham Brown in his summary of conclusions remarks that it is very difficult to see how this condition of raised excitability can be transmitted to the offspring, and this comment which might be made in reference to any of the alleged cases certainly applies with special cogency to the present example. He then calls special attention to three observations: 1. That guinea pigs which had a "trophic" change in the foot, as a result of division of the great sciatic nerve, have repeatedly been seen to nibble the feet of other guinea pigs which had this change in the foot from the same causes. 2. That accidental injury to the toes may be followed by the Brown-Séquard phenomenon in an otherwise normal animal. 3. That in several instances the young of guinea pigs which exhibited the phenomenon have been noticed to have one or more toes eaten off by the mother.