"Every one knows how a garment, after having been worn a certain time, clings to the shape of the body better than when it was new; there has been a change in the tissue, and this change is a new habit of cohesion. A lock works better after being used some time; at the outset more force was required to overcome certain roughness in the mechanism. The overcoming of their resistance is a phenomenon of habituation. It costs less trouble to fold a paper when it has been folded already; ... and just so in the nervous system the impressions of outer objects fashion for themselves more and more appropriate paths, and these vital phenomena recur under similar excitements from without, when they have been interrupted a certain time." Not in the nervous system alone. A scar anywhere is a _locus minoris resistentiæ_, more liable to be abraded, inflamed, to suffer pain and cold, than are the neighboring parts. A sprained ankle, a dislocated arm, are in danger of being sprained or dislocated again; joints that have once been attacked by rheumatism or gout, mucous membranes that have been the seat of catarrh, are with each fresh recurrence more prone to a relapse, until often the morbid state chronically substitutes itself for the sound one. And in the nervous system itself it is well known how many so-called functional diseases seem to keep themselves going simply because they happen to have once begun; and how the forcible cutting short by medicine of a few attacks is often sufficient to enable the physiological forces to get possession of the field again, and to bring the organs back to functions of health. Epilepsies, neuralgias, convulsive affections of various sorts, insomnias, are so many cases in point. And, to take what are more obviously habits, the success with which a 'weaning' treatment can often be applied to the victims of unhealthy indulgence of passion, or of mere complaining or irascible disposition, shows us how much the morbid manifestations themselves were due to the mere inertia of the nervous organs, when once launched on a false career.