=Cerebral Blood-supply.=--All parts of the cortex, when electrically excited, produce alterations both of respiration and circulation. The blood-pressure somewhat rises, as a rule, all over the body, no matter where the cortical irritation is applied, though the motor zone is the most sensitive region for the purpose. Slowing and quickening of the heart are also observed. Mosso, using his 'plethysmograph' as an indicator, discovered that the blood-supply to the arms diminished during intellectual activity, and found furthermore that the arterial tension (as shown by the sphygmograph) was increased in these members (see Fig. 50). So slight an emotion as that produced by the entrance of Professor Ludwig into the laboratory was instantly followed by a shrinkage of the arms. The brain itself is an excessively vascular organ, a sponge full of blood, in fact; and another of Mosso's inventions showed that when less blood went to the legs, more went to the head. The subject to be observed lay on a delicately balanced table which could tip downward either at the head or at the foot if the weight of either end were increased. The moment emotional or intellectual activity began in the subject, down went the head-end, in consequence of the redistribution of blood in his system. But the best proof of the immediate afflux of blood to the brain during mental activity is due to Mosso's observations on three persons whose brain had been laid bare by lesion of the skull. By means of apparatus described in his book, this physiologist was enabled to let the brain-pulse record itself directly by a tracing. The intra-cranial blood-pressure rose immediately whenever the subject was spoken to, or when he began to think actively, as in solving a problem in mental arithmetic. Mosso gives in his work a large number of reproductions of tracings which show the instantaneity of the change of blood-supply, whenever the mental activity was quickened by any cause whatever, intellectual or emotional. He relates of his female subject that one day whilst tracing her brain-pulse he observed a sudden rise with no apparent outer or inner cause. She however confessed to him afterwards that at that moment she had caught sight of a _skull_ on top of a piece of furniture in the room, and that this had given her a slight emotion.