M., aged 20; convulsions at the age of nine months. Later, he suffered from poor sleep (enuresis nocturna); was nervous, and developed tardily and imperfectly. From the time of puberty he was irritable, showed evil inclinations; was lazy; could not be taught, and in all trades proved, to be of no use. He grew no better even in the House of Correction. He was made a marine, but there, too, he proved useless. When he returned home he stole from his parents, and spent his time in bad company. He did not run after women, but gave himself up passionately to masturbation, and occasionally indulged in sodomy with bitches. His mother suffered with mania menstrualis periodica. An uncle was insane, and another an inebriate. The examination of M.’s brain showed morbid changes of the frontal lobes, of the first and second temporal convolutions, and of a part of the occipital convolutions. Case 18. Alton, a clerk in England, goes out of town for a walk. He lures a child into a thicket, and returns after a time to his office, where he makes this entry in his note-book: “Killed to-day a young girl; it was fine and hot.” The child was missed, searched for, and found cut into pieces. Many parts, and among them the genitals, could not be found. A. did not show the slightest trace of emotion, and gave no explanation of the motive or circumstances of his horrible deed. He was a psychopathic individual, and occasionally subject to states of depression with tædium vitæ. His father had had one attack of acute mania. A near relative suffered from mania with homicidal impulses. A. was executed. In such cases it may even happen that appetite for the flesh of the murdered victim arises, and, in consequence of this perverse coloring of the idea, parts of the body may be eaten. Case 19. Leger, vine-dresser, aged 24. From youth moody, silent, shy of people. He starts out in search of a situation. He wanders about eight days in the forest, there catches a girl twelve years old, violates her, mutilates her genitals, tears out her heart, eats of it, drinks the blood, and buries the remains. Arrested, at first he lied, but finally confessed his crime with cynical cold-bloodedness. He listened to his sentence of death with indifference, and was executed. At the post-mortem examination, Esquirol found morbid adhesions between the cerebral membranes and the brain (Gorget, “Darstellung der Prozesse Leger, Feldtmann,” etc., Darmstadt, 1827).