Troubles fell thick and fast upon Isabel and her husband. Death within three years had made cruel sport of all their plans; and the support of England, long held in the balance by Ferdinand, to be bought when it was worth the price demanded, had now to be obtained almost at any cost. The price had increased considerably; for Henry Tudor was as keen a hand at a bargain as Ferdinand of Aragon, and closely watched events. With the usual grasping dishonesty on both sides, the treaty for the marriage of Isabel’s youngest daughter, Katharine, to the heir of England was again signed and sealed, and the young couple were married by proxy in May 1499. But Katharine was young. Her mother could hardly bring herself to part with her last-born, and send her for ever to a far country amongst strangers; and she fought hard for two years longer to delay her daughter’s going, with all manner of conditions and claims as to her future life. At length Henry of England put his foot down, and said he would wait no longer; and, worse still, he hinted that he would marry Arthur elsewhere, and throw his influence on the side of Philip of Burgundy, Ferdinand’s son-in-law, in the struggle that was already looming on the horizon. Isabel and her daughter both knew that the latter was being sent to serve her father’s political interests against her own sister and brother-in-law; but, from her birth, Katharine had been brought up in her mother’s atmosphere of uncompromising duty, surrounded by the ecstatic devotion which demanded serene personal sacrifice for higher ends; and, on the 21st May 1501, the Princess of Aragon bade a last farewell to her mother in the elfin palace of the Alhambra, to see her no more in her life of martyrdom.[80] Isabel’s health was already breaking down with labour and trouble. Disappointment faced her from every side, and as tribulations fell, bringing her end nearer, and ever nearer, the stern religious zeal that inflamed her grew more eager to do its work in her day. She had never been a weakling, as we have seen. From her youth the persecution of infidels had been as grateful to her sense of duty, as the crushing of her worldly opponents had been satisfying to her love of undisputed dominion. In all Castile, no man but her confessor, and he at his peril, had dared to say her nay; but at this juncture, when health was failing and her strength on the wane, there came to her tidings from across the sea that turned her heart to stone. Joan, her daughter, had always been somewhat wayward and rebellious at the gloomy, devout tone that pervaded her mother’s life, and Isabel had coerced her, on some occasions by forcible means, to take her part in the religious observances that occupied so large a share of attention at the Spanish court.[81]