The detailed study of embryology, however, has led to most important results apart from the particular purpose for which most of the earlier investigations in this field were originally undertaken. For the study of embryology, at first purely descriptive and comparative, was soon found to involve fundamental problems concerning the factors which control development. An egg consists of a single cell, and it develops by the division of this cell into two, then into four, eight, and so forth, until a mass of cells is produced. In some cases all these cells are to all appearance alike, or nearly alike; in others the included yolk is from the first segregated more or less completely into some cells, leaving the other cells without it. But in any case, after this process of cell-division has proceeded for a certain time, differentiation begins to set in--some cells become modified in one way, others in another, and from what was a relatively homogeneous mass an organized embryo, with highly differentiated parts, appears. The problem immediately propounds itself--what are the factors which control this differentiation? This problem is essentially a physiological one, and yet, since it arises most conspicuously in a field which has been worked by professed zoologists rather than physiologists, it has been studied more by those trained in zoology and botany than by those who have specialized in physiology. In this way, as in many other directions, such as in the study of heredity, of sex, and of the effects of the environment on the colours and structure of animals, the trend of zoology in recent years has returned towards the physiological side, and the old division which separated the sciences (but which has never so seriously affected students of plant life) is being obliterated.