The Great Ruler of the universe has made and placed upon the earth a good many millions of men, but He never made any two of them exactly alike. We may differ from every one of the countless millions who have preceded us, and still be safe. Even you and I, Algernon, may agree in many matters, and yet be very dissimilar. At least I hope so, and I presume you do also. Eccentricities of Genius. Alfonso Quanturnernit Dowdell, Frumenti, Ohio, writes to know something of the effects of alcohol on the brain of an adult, being evidently apprehensive that some day he may become an adult himself He says: “I would be glad to know whether or not you think that liquor stimulates the brain to do better literary work. I have been studying the personal history of Edgar A. Poe, and learned through that medium that he was in the habit of drinking a good deal of liquor at times. I also read that George D. Prentice, who wrote 'The Closing Year,' and other nice poems, was a hearty drinker. Will you tell me whether this is all true or not, and also what the effect of alcohol is on the brain of an adult?” It is said on good authority that Edgar A. Poe ever and anon imbibed the popular beverages of his day and age, some of which contained alcohol. We are led to believe these statements because they remain as yet undenied. But Poe did a great deal of good in that way, for he set an example that has been followed ever since, more or less, by quite a number of poets' apprentices who emulated Poe's great gift as a drinker. These men, thinking that poesy and delirium tremens went hand in hand, became fluent drunkards early in their career, so that finally, instead of issuing a small blue volume of poems they punctuated a drunkard's grave. So we see that Poe did a great work aside from what he wrote. He opened up a way for these men which eradicated them, and made life more desirable for those who remained. He made it easy for those who thought genius and inebriation were synonymous terms to get to the hospital early in the day, while the overworked waste-basket might secure a few hours of much needed rest. George D. Prentice has also done much toward weeding out a class of people who otherwise might have become disagreeable. It is better that these men who write under the influence of rum should fall into the hands of the police as early as possible. The police can handle them better than the editor can. Do not try, Alfonso, to experiment in this way. Because Mr. Poe and Mr. Prentice could write beautiful and witty things between drinks, do not, oh do not imagine that you can begin that way and succeed at last. The effect of alcohol on the brain of an adult is to congest it finally. Alcohol will sometimes congest the brain of an adult under the most trying and discouraging circumstances. I have frequently known it to scorch out and paralyze the brain in cases where other experiments had not been successful in showing the presence of a brain at all.