To effect this, give one grain of Calomel, with a quarter or half a grain of Opium, night and morning, and should the gums at the end of a week not be affected, the dose of Calomel may be doubled. Soreness of the gums, with a peculiar (mercurial) fetor of the breath and metallic taste in the mouth, may be taken as an indication that the remedy has been carried to the required extent, and this condition it is desirable to maintain until the sore heals or the symptoms subside; this may occupy four or five weeks. No good, but rather great harm, will result from carrying the use of mercury beyond this point. Should it cause much increased flow of saliva (which is very undesirable), use the remedies advised for _Salivation_, or if during a course of mercury, the sore, instead of improving, becomes worse, it should at once be discontinued. Stimulants and all kinds of excitement, as well as exposure to atmospherical changes, especially wet, should be avoided during its use; in fact, this treatment requires the greatest care throughout, and should, if possible, _be never undertaken except under proper medical supervision_. Country Sarsaparilla (163), Hydrocotyle (169), and Mudar (242), are better suited for the more advanced stages of the disease, or when it becomes constitutional. The use of the Country Sarsaparilla, however, may well be conjoined with the mercurial treatment from the very commencement. N.B.—Avoid all the crude preparations of Mercury in use by the native doctors, or sold in the bazaars; they are likely to do _incalculable mischief_.