At another time, having ascertained that his pure nitrous oxide, was eminently stimulant, he wanted to determine whether the system, in a high state of stimulation, would then be susceptible of a proportionate accession of stimulus from his new gas; like that which would be experienced by the man, who after taking one bottle of wine, drank a second; and to acquire demonstration on this nice subject, (although he was a confirmed water-drinker) to form the basis of his experiment, he drank off with all despatch a whole bottle of wine, the consequence of which was, that he first reeled, and then fell down insensibly drunk. After lying in this state for two or three hours, he awoke with a sense of nausea, head-ache, and the usual effects of intoxication. At the first return of recollection, however, undaunted by the past, the young enthusiastic philosopher called out for the _green bag_, when he breathed twelve quarts of nitrous oxide, for three or four minutes. The consequence of this was, he became a second time intoxicated, though in a less degree, when he strode across the room, and by stamping, laughing, dancing, and vociferation, found that the same effects followed, which attended his former experiment, without any increase of stimulus from the wine. All the gases that had hitherto been the subject of investigation, sunk in importance before this nitrous oxide, which the perseverance of Mr. Davy had now obtained in its pure state, in any quantity and consequently divested of that foreign admixture which rendered it usually so destructive. He had also ascertained the quantity which might safely be admitted into the lungs. Dr. Beddoes was sanguine as to its medical qualities, and conceived that, if not a specific, it might prove highly advantageous in paralysis, and pulmonary affections; and, in conjunction with these benefits he well knew it would confer importance on his own Pneumatic Institution. As Dr. B. meditated a publication expressly on this subject, he was desirous of collecting the testimony of others, for which purpose, he persuaded several of his friends to breathe this innocent, but exhilarating nitrous oxide, while they described, and he recorded their sensations.