The fourth time was immediately after breakfast. The few first inspirations affected me so little that I thought Mr. Davy had given me atmospheric air: but soon felt the warmth beginning about my chest, and spreading upward and downward, so that I could feel its progress over my whole frame. My heart did not beat so violently; my sensations were highly pleasurable, not so intense or apparently local, but of more unmingled pleasure than I had ever before experienced.[225] S. T. COLERIDGE. [225] The doses in these experiments were from five to seven quarts. VIII. _Detail of_ MR. WEDGWOOD. July 23, I called on Mr. Davy at the Medical Institution, who asked me to breathe some of the nitrous oxide, to which I consented, being rather a sceptic as to its effects, never having seen any person affected. I first breathed about six quarts of air which proved to be only common atmospheric air, and which consequently produced no effect. I then had 6 quarts of the oxide given me in a bag undiluted, and as soon as I had breathed three or four respirations, I felt myself affected and my respiration hurried, which effect increased rapidly until I became as it were entranced, when I threw the bag from me and kept breathing on furiously with an open mouth and holding my nose with my left hand, having no power to take it away though aware of the ridiculousness of my situation. Though apparently deprived of all voluntary motion, I was sensible of all that passed, and heard every thing that was said; but the most singular sensation I had, I feel it impossible accurately to describe. It was as if all the muscles of the body were put into a violent vibratory motion; I had a very strong inclination to make odd antic motions with my hands and feet. When the first strong sensations went off, I felt as if I were lighter than the atmosphere, and as if I was going to mount to the top of the room. I had a metallic taste left in my mouth, which soon went off. Before I breathed the air, I felt a good deal fatigued from a very long ride I had had the day before, but after breathing, I lost all sense of fatigue. IX. _Detail of_ MR. GEORGE BURNET. I had never heard of the effects of the nitrous oxide, when I breathed six quarts of it. I felt a delicious tremor of nerve, which was rapidly propagated over the whole nervous system. As the action of inhaling proceeds, an irresistible _appetite_ to repeat it is excited. There is now a general swell of sensations, vivid, strong, and inconceivably pleasurable. They still become more vigorous and glowing till they are communicated to the brain, when an ardent flush overspreads the face. At this moment the tube inserted in the air-bag was taken from my mouth, or I must have fainted in extacy.