The liking for strong drink, as is too well known, is often transmitted. It is remarked by Dr. Howe that 'the children of drunkards are deficient in bodily and vital energy, and are predisposed by their very organisation to have cravings for alcoholic stimulants. If they pursue the course of their fathers, which they have more temptation to follow and less power to avoid than the children of the temperate, they add to their hereditary weakness, and increase the tendency to idiotcy or insanity in their constitution; and this they leave to their children after them.' Whatever opinion we may form on the general question of responsibility for offences of commission or of omission, on this special point all who are acquainted with the facts must agree, admitting that in some cases of inherited craving for alcoholic stimulants the responsibility of those who have failed and fallen in the struggle has been but small. 'The fathers have eaten sour grapes, and the children's teeth are set on edge.' Robert Collyer of Chicago, in his noble sermon 'The Thorn in the Flesh,' has well said, 'In the far-reaching influences that go to every life, and away backward as certainly as forward, children are sometimes born with appetites fatally strong in their nature. As they grow up the appetite grows with them, and speedily becomes a master, the master a tyrant; and by the time he arrives at manhood, the man is a slave. I heard a man say that for eight-and-twenty years the soul within him had had to stand like an unsleeping sentinel, guarding his appetite for strong drink. To be a man at last under such a disadvantage, not to mention a saint, is as fine a piece of grace as can well be seen. There is no doctrine that demands a larger vision than this of the depravity of human nature. Old Dr. Mason used to say that "as much grace as would make John a saint, would hardly keep Peter from knocking a man down."'