As a result of the conflict between the toxins and the defensive forces
of the body, certain vital processes are set free in the blood and in
the cells which seem to possess a highly specialized power of defense
against any subsequent attack. Pasteur, in his researches on the subject
of rabies, developed this power of resistance by inoculating into
rabbits the rabies infection of a monkey. Monkey rabies is not a severe
form and is scarcely felt by the ordinary rabbit, but if the infective
material (usually part of the spinal cord) of the monkey-infected rabbit
is transferred to a second rabbit, the disease becomes more severe; and
if the disease is passed from animal to animal, it may be built up into
as severe a form as desired, up to the maximum. Pasteur found that by
inoculating an individual with a one-day rabbit, that is, with the
weakest brand of infection killing a rabbit in one day, and the next day
with a two-day rabbit, that the person could receive this two-day
inoculation without discomfort or danger because of the greater
antagonism acquired by the preceding inoculation. Continuing the
inoculations for fourteen days and making the strength of the infection
stronger each day, at the end of the period it was found that the
fourteenth inoculation, strong enough to produce the disease and kill a
fresh subject, had, on account of the preceding inoculations, produced
ability to withstand or counteract the actual disease developing perhaps
at the same time. Fortunately, in the case of this disease, the shortest
period for its development is fifteen days, and often it is a month or
more after the bite of the dog before the disease develops. By
successive inoculation of increasing strength for fourteen days, the
system will have acquired a habitude to the disease which prevents the
normal effects.
Diphtheria is prevented in much the same way, except that in this case
horses are used, their blood being strengthened to resist the disease by
successive inoculations of the diphtheria poison. It is probable that
all the bacterial diseases which exert their influence through the
transmission of toxins in the blood may be counteracted by the
production of an antitoxin when once the method of building up this
antitoxin has been learned. At present, rabies, tetanus, diphtheria, and
cerebrospinal meningitis are the four diseases for which antitoxin is
made commercially and generally used. For a great many years, scientists
have labored without success to find an antitoxin for consumption, and
within the last year extensive experiments have been made in the
American army on the use of antitoxin for typhoid fever.
_Natural immunity._
Public-domain text, read in full here on John Shaqi.
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