One need but mention such fundamental, and indeed indispensable, conceptions of the natural philosopher as those of atoms and forces: or that of attraction considered as action at a distance; or that of potential energy; or the antinomies of a vacuum and a plenum; to call to mind the metaphysical background of physics and chemistry; while, in the biological sciences, the case is still worse. What is an individual among the lower plants and animals? Are genera and species realities or abstractions? Is there such a thing as Vital Force? or does the name denote a mere relic of metaphysical fetichism? Is the doctrine of final causes legitimate or illegitimate? These are a few of the metaphysical topics which are suggested by the most elementary study of biological facts. But, more than this, it may be truly said that the roots of every system of philosophy lie deep among the facts of physiology. No one can doubt that the organs and the functions of sensation are as much a part of the province of the physiologist, as are the organs and functions of motion, or those of digestion; and yet it is impossible to gain an acquaintance with even the rudiments of the physiology of sensation without being led straight to one of the most fundamental of all metaphysical problems. In fact, the sensory operations have been, from time immemorial, the battle-ground of philosophers. I have more than once taken occasion to point out that we are indebted to Descartes, who happened to be a physiologist as well as a philosopher, for the first distinct enunciation of the essential elements of the true theory of sensation. In later times, it is not to the works of the philosophers, if Hartley and James Mill are excepted, but to those of the physiologists, that we must turn for an adequate account of the sensory process. Haller’s luminous, though summary, account of sensation in his admirable “Primæ Lineæ,” the first edition of which was printed in 1747, offers a striking contrast to the prolixity and confusion of thought which pervade Reid’s “Inquiry,” of seventeen years’ later date.[56] Even Sir William Hamilton, learned historian and acute critic as he was, not only failed to apprehend the philosophical bearing of long-established physiological truths; but, when he affirmed that there is no reason to deny that the mind feels at the finger points, and none to assert that the brain is the sole organ of thought,[57] he showed that he had not apprehended the significance of the revolution commenced, two hundred years before his time, by Descartes, and effectively followed up by Haller, Hartley, and Bonnet, in the middle of the last century.