Cholera gradually made its way in subsequent years through Persia to Russia, and at last to Western Europe; but it was not until late in the year 1831 that Indian cholera arrived for the first time in England, and in the following year it caused something like a panic. There have been at least three subsequent outbursts of Indian cholera (before that of the year 1908) which have reached Europe, and two of these have reached England and caused profound alarm and anxiety. That in 1854 reached us just before the Crimean War, and caused such rapid and numerous deaths in London, especially in the West End (St. James’s, Westminster), that the corpses were removed in carts as in the days of the plague. It was then that the Broad Street pump became famous, and the carefully demonstrated history of a cesspool leaking into the well of the pump, of the existence of a cholera patient in the house to which the cesspool was attached and of the infection with cholera of healthy people who sent all the way from Hampstead to fetch what they thought was the beautifully pure, cool, and palatable water of Broad Street, St. James’s, caused a most vivid and salutary impression on the public mind. The “water-carriage” of the cholera infection was established as a fact, and the subsequent abolition of surface wells and pumps, as well as of cesspools, in London and other cities was the result. Indeed, the active development of sanitation and sanitary measures of all kinds in Great Britain may be traced to the panic caused by the cholera in 1854 and to the well-founded conviction that it was in the power of the community, by the construction of sewers and the provision of untainted water-supply, to protect itself against such disaster in the future. Years passed by, and still the actual germ of cholera was unknown. In India it was not even admitted that its diffusion was especially connected with water-supply. The methods of observing with the microscope those minute swarming organisms which are called “bacteria” became immensely improved. They were isolated, cultivated in purity, and the activity of a vast number of different kinds of different shapes, sizes, and modes of growth was ascertained. They were distinguished according to their shape as bacilli, spirilla, micrococci, and so on, and separate kinds were characterised—one producing ordinary putrefaction, another the souring of milk, another the “cheesing” of the same fluid, another the destruction of teeth and of bone, another the terrible anthrax of cattle or wool-sorters’ disease, another (a spiral thread in the blood this!) the recurrent fever of East Europe—each producing its own special poison or other chemical substance.