of diphtheria is just like that of the ordinary buccal mucus; indeed, nearly all of the acutest infectious diseases are attributed to these ubiquitous micrococci, indistinguishable from each other in most instances, and divided into species solely on the score of their assumed physiological effects. Admitting all that the most ardent advocates of the germ theory can claim for it, there are at least three possible ways in which filth and fungi may be connected. 1. Taking the view of Naegeli and others as regards the mutability of the bacteria, it is conceivable that the common "scavenger" microphytes may acquire pathogenic properties by successive generations of development amid the products of certain decomposing substances. In favor of this conception may be cited the seemingly gradual intensification of "filth poisoning" in numerous instances; sore throats of a less septic type forerunning outbreaks of diphtheria; diarrhoeal derangements preceding enteric fever; and, furthermore, Koch has found both bacillus-spores and micrococci in surface soils, the latter organisms preponderating where the earth is subjected to excremental soakage. 2. Or, accepting the specific classification of the schizomycetes, it may be supposed that some pathogenic germs obtain favorable intermediate conditions for their development and multiplication in these products of decomposition; a supposition almost necessary if the specific-germ theory be applied to enteric or choleraic discharges. 3. Finally, if it be conceded that desiccated spores may retain their specific vitality indefinitely, and be air-wafted almost unboundedly, the predisposing action of our filth emanations maybe imagined to be cumulative, slowly undermining the individual powers of resistance, or rendering certain cell groups an easier prey to the intruding organisms in the struggle for existence. Which of these hypotheses, if either of them, will ultimately prevail is a question only to be decided by experimental investigations which are beset by a multitude of difficulties and sources of error.--_Med. Record_. * * * * * HORSE MEDICINE BIT.