Scientific American Supplement, No. 315, January 14, 1882Various
Science
Scientific American Supplement, No. 315, January 14, 1882
Various
Science -- Periodicals
_Preparation._--The alcoholic mother lye from chinamine is evaporated
down and protractedly exhausted with boiling ligroine, whereby
conchinamine and a small quantity of certain amorphous bases are
dissolved out. Upon cooling the greater part of the amorphous bases
precipitates out. The ligroine solution is then first treated with
dilute acetic acid, and then with a dilute solution of caustic soda,
whereupon a large quantity of a resinous precipitate is formed. This
is kneaded up with lukewarm water to remove adherent soda, and then
dissolved in hot alcohol. The alcoholic solution is saturated with
nitric acid, which has been previously diluted with half its volume of
water, and the whole set aside for a few days to crystallize. The
crystals of conchinamine nitrate are purified by recrystallization
from boiling water. On dissolving these pure crystals of the nitrate
in hot alcohol of 60 per cent., and adding ammonia, absolute pure
conchinamine separates out on cooling.
_Composition._--Conchinamine may be represented by the formula
C_{19}H_{24}N_{2}O_{2}, without water of crystallization.
_Properties._--Conchinamine is easily soluble in hot alcohol of 60 per
cent., and in ether and ligroine, from which solutions it crystallizes
in quadrilateral shining prisms. It is extremely soluble in
chloroform, but almost insoluble in water. It melts at 121 deg. C.,
forming crystalline stars on cooling.
_Salts._--The salts of conchinamine, like the base itself, have much
in common with chinamine, but are, as a rule, more easily
crystallizable. They are prepared by neutralizing an alcoholic
solution of the base with the acid in question.--_Chemist and
Druggist._
* * * * *
CHINOLINE.
The valuable properties of which chinoline has been found to be
possessed have led to its admission as a therapeutic agent, and the
discoverer of these properties, Jul. Donath, of Baja, in Hungary, in a
paper sent to the _Berichte der deutschen chemischen Gesellschaft_,
September 12, 1881, gives the following further details as to this
interesting substance.
_Antiseptic Properties._--Chinoline appears to be an excellent
antiseptic. The author found that 100 grammes of a Bucholze's solution
for the propagation of bacteria, charged with 0.20 g. of chinoline
hydrochlorate, had remained perfectly clear and free from bacteria
after standing forty-six days exposed to the air, while a similar
solution, placed under the same conditions, without chinoline, had
turned muddy and contained bacteria after only twelve days' standing.
_Antizymotic Properties._--Chinoline, even in the proportion of 5 per
cent., does not prevent alcoholic fermentation, while in as small a
quantity as 0.20 per cent. it does not prevent lactic acid
fermentation.
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