paroxysms of fever. Quinine is, when given for a long period of time, a true poison to the vaso-motor nerves. The question, then, is to replace quinine, and the alkaloids which possess an analogous physiological action, by an agent the efficacy of which against, chronic malarial poisoning may be greater and the dangers of its employment less. THE LEMON FOR MALARIA. A happy chance has led Dr. Magliori to the discovery of an agent of this sort which was traditionally in use by certain Italian families. It is an exceedingly simple thing--merely a decoction of lemon. It is prepared by cutting up one lemon, peel and all, into thin slices, which are then put into three glassfuls of water and the whole boiled down to one glassful. It is then strained through linen, squeezing the remains of the boiled lemon, and set aside for some hours to cool. The whole amount of the liquid is then taken fasting. It is well known that in Italy, Greece, and North Africa, they often use lemon juice or a decoction of lemon seeds, as a remedy in malarial fevers of moderate intensity; and in Guadaloupe they use for the same purpose a decoction of the bark of the roots of the lemon tree. All these popular practices tend to show that the lemon tree produces a febrifuge substance, which resides in all parts of the plant, but which would seem to be most abundant in the fruit. In fact, among the popular remedies employed against malarial infection, that which I have just described is the most efficacious, for it can be employed with good effects in acute fevers. But it is especially advantageous in combating the chronic infection, which is rebellious to the action of quinine, and in removing or moderating its deplorable effects.