_Subcutaneous injections_ of neutralized orange juice failed to cure scurvy in guinea-pigs; Harden and Zilva were equally unsuccessful with large doses of their concentrated lemon juice. This is of interest in view of the marked therapeutic result which Shiga obtained with subcutaneous injections of the water-soluble vitamine in pigeons suffering from polyneuritis. It should be added that Holst and Froelich (1912) failed to cure scurvy in guinea-pigs by intraperitoneal inoculations of orange juice. _Lemon juice or orange juice may be dried_ and lose little of its antiscorbutic power. In their paper of 1912 Holst and Froelich reported the efficacy of lemon juice evaporated in a vacuum, and recently Harden and Zilva published experiments which proved that "by evaporating the treated lemon juice to dryness in an acid medium an active dry residue is obtained." Still more recently Givens has shown that orange juice reduced to a powdered form by means of a spraying process has lost little of the antiscorbutic factor. These results prove that under certain conditions the antiscorbutic factor withstands drying; one of these favorable influences is an acid reaction, and another, rapidity of desiccation.[40] [40] Preserved mulberries which had been sugared and cooked for one-quarter to one-half an hour were found by Holst and Froelich (1912) to possess good antiscorbutic power three months later. =Lime Juice.=--Recently an investigation of lime juice has been carried out by Chick, Hume and Skelton. They were "unable to detect any significant protection in a daily ration of from 5 to 10 c.c. of preserved lime juice which was several months or a year or more old." Crude lime juice of various ages had slight antiscorbutic value, affording only partial protection in a daily ration of 5 c.c. Even fresh juice was found not to be very efficacious compared with lemon juice. The authors conclude that "the relative value of these two fruit juices deduced from the trials with monkeys is therefore in accord with that obtained in the experiments with guinea-pigs, _i.e._, the value of fresh lemon juice is approximately four times that of fresh lime juice." Holst and Froelich in 1907 carried out a similar but less extensive investigation. They also found that lime juice was unable to protect guinea-pigs from scurvy. Fuerst, a co-worker of Holst, continued this work, and in his article of 1912 stated that guinea-pigs should not be protected by a daily addition to their ration of 25 g. of lime juice; these guinea-pigs received a mixed diet consisting of dry vegetables, butter, almonds and malt extract. These two reports of the Norwegian investigators on this interesting subject should have attracted attention.